abstract：OBJECTIVE:To investigate molecular events of exocytosis in cultured human pheochromocytoma cells with stimulation. METHODS:The cultured pheochromocytoma cells prepared from human adrenal pheochromocytoma tumor were stimulated for the release of catecholamines by depolarization with the administration of 50 mmol/L KCl....

journal_title：Chinese medical journal

authors： Lee YS,Chou YY

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To detect 3 kinds of N-ras mutations in Chinese patients with acute myeloid leukemia (AML). METHODS:In vitro DNA amplification followed by oligonucleotide dot analysis were used to study N-ras gene mutations in 43 cases of acute myeloid leukemia (AML). 25 healthy people were used as controls. Patients were s...

journal_title：Chinese medical journal

authors： Guo W,Tang B,Xu S,Yao Y,Ye D

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence, severity, clinical manifestations and immunological features relevant to liver involvement in 135 cases of primary Sjögren's syndrome. METHODS:One hundred and thirty-five patients with definite primary Sjögren's syndrome were analyzed retrospectively for liver involvement by the ab...

journal_title：Chinese medical journal

authors： Zhang Z,Dong Y

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To elucidate the transmission dynamic and epidemic trend of bancroftian filariasis occurred under the condition with no control measure taken 5 years after elimination of filariasis. METHODS:A 10-year longitudinal observation (from 1984 to 1994) was made in Huayuan Village in Shengli Township of Tancheng Cou...

journal_title：Chinese medical journal

authors： Wang P,Wang F,Sun Y,Wang J,Kou J,Huang Y,Kang X,Wan G,Liang Y,Wang Q

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To study the preventive effect of artemether (Art) in protecting the people from schistosome infection during flood fighting in schistosomiasis endemic area of Poyang Lake, Jiangxi Province. METHODS:From mid July to mid August in 1996, the water level in Poyang Lake rose due to torrential rains and 2 embankm...

journal_title：Chinese medical journal

authors： Song Y,Xiao S,Wu W,Zhang S,Xie H,Xu X,Hu X,Cui Q,Chen M,Zheng J

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To explore the association of human leukocyte antigen (HLA) with pregnancy induced hypertension (PIH). METHODS:We oligotyped HLA-DQA1, -DQB1 locus of 30 Chinese PIH families and 14 control families in Shanghai area by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) hybridization method ...

journal_title：Chinese medical journal

authors： Mao Y,Zhang Z,Fan L,Wu Q,Jiang L,Yang J,Yao F

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To analyze the relationship between the proto-oncogene c-fos change and neuronal degeneration in the hippocampus of the patients with Alzheimer's disease. METHODS:The post mortem human hippocampal tissues were divided into three groups, namely, the aged, the young and Alzheimer's disease (AD) groups. Each gr...

journal_title：Chinese medical journal

authors： Lu W,Mi R,Tang H,Liu S,Fan M,Wang L

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To study the changes of creatine kinase MM (CK-MM) isoforms in Duchenne muscular dystrophy (DMD) patients. METHODS:Serum samples from 49 DMD patients and 40 control subjects were collected for CK-MM isoforms measurement. CK-MM isoforms were separated within 30 minutes by electrophoresis on agarose gel with a...

journal_title：Chinese medical journal

authors： Zhao X,Bi C,Yang Z

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To compare the effect of ouabain on the blood pressure of rats with that of digoxin to find the evidences of the relationship between endogenous ouabain (EO) and development of hypertension. METHODS:Sprague-Dawley rats, which were divided into 3 groups, were infused with ouabain (23 x 75 micrograms.kg-1/day,...

journal_title：Chinese medical journal

authors： Wang H,Lu Z,Yuan W

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:To review the current status of multimodality treatment and lymphadenectomy in the management of esophageal cancer. DATA SOURCES:Literature review. STUDY SELECTION:Multimodality treatment and lymphadenectomy in esophageal cancer. DATA EXTRACTION:Results in research papers published selected by literature sea...

journal_title：Chinese medical journal

authors： Law S,Wong J

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:To assess the existence of a possible infectious factor in varicocele-related infertility. METHODS:A total of 925 seminal plasmas from 590 infertile men with varicocele and 335 infertile patients without palpable varicocele were cultured for Ureaplasma urealyticum infection, and routine semen analysis was ma...

journal_title：Chinese medical journal

authors： Li H,Guo Y,Wang Y,Sun X

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:A human promyelocytic leukemia (APL) cell line NB4 was used to demonstrate the synergistic effects between all-trans retinoic acid (ATRA) and prostaglandin E2 (PGE2) on growth inhibition and cytodifferentiation induction. METHODS:NB4 cells were cultured in the presence of either ATRA or PGE2 as a single agen...

journal_title：Chinese medical journal

authors： Chen Z,Breitman TR

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation among retinal fluorescein angiography, blood viscosity, and other factors in patients with open angle glaucoma (POAG). METHODS:Multiple step regression analysis was made to investigate the correlation between each of the following blood vessel filling times: the arm-choroid (A-...

journal_title：Chinese medical journal

authors： Liu X,Zhou W,Ye T,Ge J,Cai X,Cheng A,Lin Y,Liang L,Tang H,Chen Z

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate the complications of laparoscopic cholecystectomy in China. METHODS:All Chinese articles about laparoscopic cholecystectomy published between April 1994 and November 1995 were identified through CMCC (Chinese Medical Computerized Contents). From more than 600 titles, 105 articles were screened...

journal_title：Chinese medical journal

authors： Huang X,Feng Y,Huang Z

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine antiganglioside antibodies (AGA) in cerebrospinal fluid (CSF) of children with neuropsychiatric lupus erythematosus (NPLE), and to investigate their association with clinical manifestations and other laboratory tests. METHODS:An enzyme linked immunoabsorbent assay was used to detect AGA in 22 CS...

journal_title：Chinese medical journal

authors： Chen Y,Wu F,Hou L,Ma S,He X

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and the clinico-pathological manifestations in patients with immunoglobulin nephropathy (IgAN). METHODS:A flanking primer pair and an insertion-specific primer pair were used to perform two polyme...

journal_title：Chinese medical journal

authors： Chen X,Liu S,Ye Y,Xu Q

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:The management strategies after acute myocardial infarction (AMI) have been evolving from simple supportive treatment to various protocols of thrombolytic therapies, and then to mechanical revascularization by balloon angioplasty in recent years. However, controversies still exist between which is the best tr...

journal_title：Chinese medical journal

authors： Lee SW,Chan HW,Lam L

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To study the mode of presentation, the tumor, nodes, metastasis (TNM) staging and the efficacy of multimodal treatment of breast cancer among Chinese women treated in Queen Mary Hospital. METHODS:The available records of all breast cancer patients treated between January 1980 and December 1994 were reviewed....

journal_title：Chinese medical journal

authors： Chow LW,Ting AC,Cheung KL,Au GK,Alagaratnam TT

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether or not estrogen receptor and other sex hormone receptors are present in hemangioma tissues of children. METHODS:Fifty-two specimens of hemangiomas were taken from 52 children. The specimens were doubly stained with hematoxylin-eosin and enzyme-linking affinity immunohistochemistry. The...

journal_title：Chinese medical journal

authors： Lui W,Zhang S,Hu T,Wei F,Gao Y,Cheng N

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To investigate the histologic and histogenetic relationship between various types of rhabdomyosarcomas (RMS) and embryonal skeletal muscle (ESM) for further understanding of the histogenesis, classification and pattern of differentiation of RMS. METHODS:Fifty cases of variant types of RMS and 20 cases of ESM...

journal_title：Chinese medical journal

authors： Lai R,Tian Y,An J,Zhou MW,Zou G,Li W

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of transcranial Doppler ultrasound (TCD) and digital subtraction angiography (DSA) in identifying the clinical and hemodynamic relationship between intra- and extra-cranial circulation and subclavian steal syndrome. METHODS:Sixteen patients were collected. The intra- and extra-cranial...

journal_title：Chinese medical journal

authors： Huang Y,Gao S,Wang B,Li S

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To measure serum 7S collagen (7S-C) and type VI collagen (VI-C) levels by radioimmunoassay (RIA) in Chinese patients with various liver disorders and in CCl4-treated SD rats, and to investigate the significance of the elevated levels of serum 7S-C and VI-C. METHODS:Serum 7S-C and VI-C levels were measured in...

journal_title：Chinese medical journal

authors： Ji X,Li S,Kong X,Xu G,Chen J,Dai X

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the diagnosis and aggressive surgical approach for brainstem tumors. METHODS:A series of 24 adult patients with brainstem tumors were involved. Magnetic resonance (MR) imaging was performed on all patients. Surgical technique, potential risk and management of complications were described. RESULT...

journal_title：Chinese medical journal

authors： Xu Q,Bao W,Mao R

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of different doses of intravenous domestic urokinase. METHODS:One thousand and twenty three cases of acute myocardial infarction within 6 hours after acute onset were divided randomly into two groups with 539 cases in the low dose group (urokinase 22,000IU/kg, total dose not lower ...

journal_title：Chinese medical journal

authors：

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To determine whether mutation of the coding or junction region of glucokinase gene (GCK) is also the pathogenic cause of the common form of non-insulin-dependent diabetes mellitus (NIDDM) in Chinese. METHODS:Single strand conformation polymorphism (SSCP) analysis was performed after the 12 exons and junction...

journal_title：Chinese medical journal

authors： Xiang K,Wu S,Zheng T,Sun D,Wang Y,Pu L

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The P53 tumor suppressor gene shows the most frequent genetic alteration in human tumors. Mutation, deletion and rearrangement of P53 gene have been found in several types of neoplasm including osteosarcoma. The present study is to clarify the status of abnormalities of this gene in osteosarcoma in China. MA...

journal_title：Chinese medical journal

authors： Guo W,Wang X,Feng C

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To explore the pathogenesis of glucose metabolic disorder and insulin resistance in critically ill children under severe stress. METHODS:To test glucose, lactate, glucagon, insulin, c-peptide, cortisol levels in 50 critically ill children. While we measured 125I-insulin binding to erythrocytes of 13 critical...

journal_title：Chinese medical journal

authors： Xu F,Yang X,Lu Z,Kuang F

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To reveal the sequence of events of osteoclastic resorption taking place in the cortical bone of the femoral neck in aged women. MATERIAL AND METHODS:The cross sections of cortical bones of the femoral neck from 7 aged women who underwent endoprosthetic replacement for intracapsular hip fracture, were proces...

journal_title：Chinese medical journal

authors： Chai B,Tang X,Li H

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:To investigate the role of AC-cAMP system in the transmission of the action of the growth hormone releasing hormone (GRH) on growth hormone (GH) release in pituitary GH-secreting adenomas. METHODS:The effects of GRH (10(-7) mol/L) on intracellular cAMP levels and GH release and the effects of AC-cAMP stimula...

journal_title：Chinese medical journal

authors： Shi Y,Deng J,Yin J

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of alveolar macrophages (AMs), fibroblasts and interstitial cells on development of lung fibrosis, and the interactions among TGF-beta 1 PDGF and IGF-1 and these cytokines-effects on lung fibrosis. MATERIAL AND METHODS:Expressions of TGF-beta 1, PDGF and IGF-1 mRNA in the lung ce...

journal_title：Chinese medical journal

authors： Li H,He B,Que C,Weng B

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To examine the effect of selective head cooling (SHC) on brain cell membrane activity involving ATPase, phospholipase A2, content of total membrane phospholipids during postischemic reperfusion, so as to elucidate the possible underlying mechanism on resuscitating effect of SHC. MATERIALS AND METHODS:Complet...

journal_title：Chinese medical journal

authors： Duan M,Li D,Xu J

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:To explore the mechanism of cisplatin resistance and its reversion in human ovarian cancer. MATERIALS AND METHODS:A cisplatin resistant cell subline of SKOV3, SKOV3/cp, was established, and a xenograft mice model of human ovarian cancer was established by microencapsulation technology. Various biochemical ch...

journal_title：Chinese medical journal

authors： Liang Z,Bian D

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To investigate osteoclastic resorption in trabeculae of osteoporotic femoral head. METHODS:Osteoporotic femoral heads were collected from 7 aged women with an average age of 72.4 years, who underwent endoprosthetic replacement for intracapsular hip fracture. Femoral head trabeculae from 3 young adults killed...

journal_title：Chinese medical journal

authors： Chai B,Tang X,Zhou W,Li H

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of cordocentesis for prenatal diagnosis of various fetal diseases. PATIENTS AND METHODS:Fetal blood sampling was performed in 30 pregnancies from gestational week 19 to 36 for various prenatal diagnoses. We used Aloka SSD-650 real-time ultrasound scanner with 3.5 mHz curvi...

journal_title：Chinese medical journal

authors： Xiang Y,Sun N,Chang X,Bian X,Wang F

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To understand whether very low density lipoprotein (VLDL) and oxidatively modified very low density lipoprotein (OX-VLDL) can stimulate vascular smooth muscle cells (SMCs) to express high level of monocyte chemotactic protein (MCP-1) mRNA. METHODS:LDL and VLDL were isolated from normal blood donors by densit...

journal_title：Chinese medical journal

authors： Ruan Q,Deng Z,Song J

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice. MATERIALS AND METHODS:Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastog...

journal_title：Chinese medical journal

authors： Hau DM,Feng Y,Chen WC,Lin IH,Chen KT,Lin SS,Wang MI

更新日期：1996-02-01 00:00:00

abstract：:Since 1979 we have treated 149 patients with duodenal ulcer by extended parietal cell vagotomy (EPCV). Electron microscopy of parietal cells from gastric body mucosa and gastric acid secretory test were carried out in 22 randomly selected patients before and after EPCV. It was shown that before EPCV the ultrastructure...

journal_title：Chinese medical journal

authors： Li S,Chen P,An P,Liu C,Yuan S,Chen L

更新日期：1995-12-01 00:00:00

abstract：:Four calcium channel blockers, i.e. nifedipine, verapamil, cinnarizine and tetrandrine are currently available and used widely in treating cardiovascular diseases. To confirm the effects, if any, of calcium channel blockers on cirrhotic patients with portal hypertension, a study was performed on esophageal variceal pr...

journal_title：Chinese medical journal

authors： Li D,Lu H,Li X,Quan Q,Li X,Lu W

更新日期：1995-11-01 00:00:00

abstract：:The effects of hypoxic endothelial cell conditioned medium (HECCM) on proliferation and collagen synthesis of cultured porcine pulmonary arterial smooth muscle cells (PASMCs) were studied by 3H-thymidine (3H-TdR) and 3H-proline incorporations, image analysis for determination of DNA content and colorimetric assay usin...

journal_title：Chinese medical journal

authors： Sun B,Yuan Y,Zhang W,Che D

更新日期：1995-11-01 00:00:00

abstract：:The results of 31 cases of sutureless esophagogastrostomy by intraluminal elastic circular ligation (IECL) with the biodegradable supporting tube were reported. The fate of the supporting tube could be tracked satisfactorily by X-ray. The tube-dislodge time was 15.03 +/- 2.23 days and unaffected by the size of support...

journal_title：Chinese medical journal

authors： Chen L,Zhang Y,Du X,Wang Q,Zhang Z

更新日期：1995-10-01 00:00:00